The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys.

TitleThe 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys.
Publication TypeJournal Article
Year of Publication1996
JournalNeuroreport
Volume8
Issue1
Pagination49-54
Date Published1996
ISSN0959-4965
Abstract

Substantial evidence indicates that serotonin receptors are involved in the regulation of acetylcholine release in CNS regions important to mnemonic processes, and may thus be exploited pharmacologically as targets for memory improvement. In the present study, the (R) and (S) isomers of a potent serotonin (5-HT3) receptor ligand, RS-56812 were evaluated for potential memory effects in five macaques trained to perform a delayed matching-to-sample (DMTS) task. While both isomers enhanced certain aspects of task performance, the (R) isomer produced more systematic improvements. This differential sensitivity to the isomers in regard to DMTS performance appears to parallel the higher 5-HT3 receptor affinity of the R enanantiomer. The results are consistent with a potential therapeutic role for RS-56812 in disorders involving cognitive decline.

URLhttp://Insights.ovid.com/pubmed?pmid=9051751
Short TitleNeuroreport
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