Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation.

TitleAcute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation.
Publication TypeJournal Article
Year of Publication2015
JournalDrug and alcohol dependence
Volume154
Pagination100-4
Date Published2015
ISSN0376-8716
Abstract

The development of ethanol dependence is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis and activation of type II glucocorticoid receptors (GR). These effects may contribute to withdrawal-associated anxiety, craving and relapse to drinking. The present studies examined acute and oral administration of the novel, selective and competitive GR antagonist ORG 34517 on the severity of ethanol withdrawal.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0376-8716(15)00317-8
DOI10.1016/j.drugalcdep.2015.06.018
Short TitleDrug Alcohol Depend
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