Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.

TitleAge and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
Publication TypeJournal Article
Year of Publication2008
JournalAlcoholism, clinical and experimental research
Volume32
Issue6
Pagination929-36
ISSN0145-6008
Abstract

Polyamines are synthesized and released in high concentrations during CNS development. These agents can potentiate N-methyl-D-aspartate receptor (NMDAR) function and appear to play an important role in CNS development. Previous work has shown that polyamine release is increased during ethanol withdrawal (EWD). This likely promotes NMDAR overactivity and contributes to neurotoxicity during EWD, however, little is known regarding such effects in early neonatal brain. The present study compared the effects of EWD and polyamine exposure on toxicity in hippocampal slice cultures derived from postnatal day 2 (PND 2) or postnatal day 8 (PND 8) day-old rats. Due to changes in NMDAR subtypes and response to polyamines, we predicted that slices taken from PND 2 pups would be more sensitive to EWD and polyamine challenge.

URLhttp://dx.doi.org/10.1111/j.1530-0277.2008.00649.x
DOI10.1111/j.1530-0277.2008.00649.x
Short TitleAlcohol Clin Exp Res
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