Comment on "Differential rescue of light- and food-entrainable circadian rhythms".

TitleComment on "Differential rescue of light- and food-entrainable circadian rhythms".
Publication TypeJournal Article
Year of Publication2008
JournalScience (New York, N.Y.)
Volume322
Issue5902
Pagination675; author reply 675
Date Published2008
ISSN0036-8075
Abstract

Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=18974333
DOI10.1126/science.1161284
Short TitleScience
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