Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment.

TitleCytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment.
Publication TypeJournal Article
Year of Publication2004
JournalAlcoholism, clinical and experimental research
Volume28
Issue12
Pagination1916-24
ISSN0145-6008
Abstract

Long-term ethanol exposure leads to increases in the expression and/or sensitivity of NMDA-type glutamate receptors, effects that may contribute to the development of cytotoxicity in the brain. The human immunodeficiency virus 1 (HIV-1) transcription factor Tat is one of many viral proteins that may contribute to the development of HIV-associated dementia (HAD) by indirectly or directly promoting excess function of NMDA receptors. Thus, these studies examined the hypothesis that long-term ethanol pre-exposure would sensitize the hippocampus to Tat-induced cytotoxicity in an NMDA receptor-dependent manner.

URLhttps://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2004&volume=28&issue=12&spage=1916
Short TitleAlcohol Clin Exp Res
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading