Disconnected circadian and cell cycles in a tumor-driven cell line.

TitleDisconnected circadian and cell cycles in a tumor-driven cell line.
Publication TypeJournal Article
Year of Publication2010
JournalCommunicative & integrative biology
Volume3
Issue6
Pagination536-9
Abstract

Cell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled in immortalized fibroblasts, resulting in a rapid rate of cell division even though the circadian rhythm is normal in these cells. Here we report that tumor-driven Lewis lung carcinoma (LLC) cells have perfectly temperature compensated circadian clocks, but the periods of their cell cycle gene expression rhythms are temperature-dependent, suggesting that their circadian and cell cycles are not connected. These data support our hypothesis that decoupling of the circadian and cell cycles may underlie aberrant cell division in tumor cells.

URLhttp://www.tandfonline.com/doi/full/10.4161/cib.3.6.12841
DOI10.4161/cib.3.6.12841
Short TitleCommun Integr Biol
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