Dopamine neuron stimulating actions of a GDNF propeptide.

TitleDopamine neuron stimulating actions of a GDNF propeptide.
Publication TypeJournal Article
Year of Publication2010
JournalPloS one
Volume5
Issue3
Paginatione9752
Date Published2010
Abstract

Neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), have shown great promise for protection and restoration of damaged or dying dopamine neurons in animal models and in some Parkinson's disease (PD) clinical trials. However, the delivery of neurotrophic factors to the brain is difficult due to their large size and poor bio-distribution. In addition, developing more efficacious trophic factors is hampered by the difficulty of synthesis and structural modification. Small molecules with neurotrophic actions that are easy to synthesize and modify to improve bioavailability are needed.

URLhttp://dx.plos.org/10.1371/journal.pone.0009752
DOI10.1371/journal.pone.0009752
Short TitlePLoS One
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