Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.

TitleExercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
Publication TypeJournal Article
Year of Publication2016
JournalCardiovascular research
Volume111
Issue3
Pagination295-306
Date Published2016
ISSN0008-6363
Abstract

Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrhythmias in mice with the CPVT1-causative missense mutation Ryr2-R2474S by restoring normal Ca(2+) handling.

URLhttps://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvw095
DOI10.1093/cvr/cvw095
Short TitleCardiovasc Res
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