HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses.

TitleHGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses.
Publication TypeJournal Article
Year of Publication2006
JournalBirth defects research. Part B, Developmental and reproductive toxicology
Volume77
Issue5
Pagination399-404
ISSN1542-9733
Abstract

The consequences of mutations in embryonic and fetal cells are serious and contribute to high prenatal sensitivity to mutagenic agents. An understanding of the factors that influence the yield of such mutations is important for management of adverse effects of perinatal exposures. Resistance to 6-thioguanine (6-TG) can be utilized to study mutational events at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus. HGPRT is X-linked and recessive. According to the Lyon hypothesis, male cells have only one X-chromosome and female cells randomly inactivate the second X-chromosome. This leads to the prediction that X-linked genes should be equally sensitive to the mutagenic effects of toxicants in male and female fetuses.

URLhttp://dx.doi.org/10.1002/bdrb.20088
DOI10.1002/bdrb.20088
Short TitleBirth Defects Res B Dev Reprod Toxicol
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