HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.

TitleHIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.
Publication TypeJournal Article
Year of Publication2013
JournalNeurobiology of disease
Volume49
Pagination169-76
ISSN0969-9961
Abstract

Human immunodeficiency virus-1 (HIV)-associated neurocognitive disorder (HAND) is a neurodegenerative disease for which there is no available neuroprotective therapy. Viral proteins, such as Tat, have been implicated as agents of neurotoxicity via multiple mechanisms, including effects by directly binding to the NMDA receptor. We evaluated the ability of the immune response against Tat to modulate neurotoxicity at glutamate receptors.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0969-9961(12)00300-2
DOI10.1016/j.nbd.2012.08.013
Short TitleNeurobiol Dis
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