Induction of rat sarcomas in rats treated with antithymocyte sera after transplantation of human cancer cells.

TitleInduction of rat sarcomas in rats treated with antithymocyte sera after transplantation of human cancer cells.
Publication TypeJournal Article
Year of Publication1979
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue4
Pagination1793-4
ISSN0027-8424
Abstract

Human cancer cells that had had high (greater than 160) tissue culture passages, when transplanted into antithymocyte-treated F344 newborn rats, caused induction of rat sarcomas in the rats within 2 or 3 subcultures, whereas human cancer cells with low (5-33) passages in vitro did not cause overt induction of rat sarcomas until after 5-10 subtransplantations. Because oncornavirus activity was not detected in either rat or human tumors, it is suggested that transforming sequences located on the human tumor cells may have been transferred to supporting rat reticulum cells in close contact with the human cancer cells.

Short TitleProc Natl Acad Sci U S A
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