Ketone bodies mediate antiseizure effects through mitochondrial permeability transition.

TitleKetone bodies mediate antiseizure effects through mitochondrial permeability transition.
Publication TypeJournal Article
Year of Publication2015
JournalAnnals of neurology
Volume78
Issue1
Pagination77-87
ISSN0364-5134
Abstract

Ketone bodies (KB) are products of fatty acid oxidation and serve as essential fuels during fasting or treatment with the high-fat antiseizure ketogenic diet (KD). Despite growing evidence that KB exert broad neuroprotective effects, their role in seizure control has not been firmly demonstrated. The major goal of this study was to demonstrate the direct antiseizure effects of KB and to identify an underlying target mechanism.

URLhttp://dx.doi.org/10.1002/ana.24424
DOI10.1002/ana.24424
Short TitleAnn Neurol
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