Kindlin-2 interacts with endothelial adherens junctions to support vascular barrier integrity.

TitleKindlin-2 interacts with endothelial adherens junctions to support vascular barrier integrity.
Publication TypeJournal Article
Year of Publication2017
JournalThe Journal of physiology
Volume595
Issue20
Pagination6443-6462
Date Published2017
ISSN0022-3751
Abstract

A reduction in Kindlin-2 levels in endothelial cells compromises vascular barrier function. Kindlin-2 is a previously unrecognized component of endothelial adherens junctions. By interacting directly and simultaneously with β- or γ-catenin and cortical actin filaments, Kindlin-2 stabilizes adherens junctions. The Kindlin-2 binding sites for β- and γ-catenin reside within its F1 and F3 subdomains. Although Kindlin-2 does not associate directly with tight junctions, its downregulation also destabilizes these junctions. Thus, impairment of both adherens and tight junctions may contribute to enhanced leakiness of vasculature in Kindlin-2 mice.

URLhttps://doi.org/10.1113/JP274380
DOI10.1113/JP274380
Short TitleJ Physiol
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