Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.

TitleLack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.
Publication TypeJournal Article
Year of Publication2015
JournalCardiovascular research
Volume106
Issue1
Pagination32-42
Date Published2015
ISSN0008-6363
Abstract

In pressure overload, left ventricular (LV) dilatation is a key step in transition to heart failure (HF). We recently found that collagen VIII (colVIII), a non-fibrillar collagen and extracellular matrix constituent, was reduced in hearts of mice with HF and correlated to degree of dilatation. A reduction in colVIII might be involved in LV dilatation, and we here examined the role of reduced colVIII in pressure overload-induced remodelling using colVIII knock-out (col8KO) mice.

URLhttps://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvv041
DOI10.1093/cvr/cvv041
Short TitleCardiovasc Res
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