Long-term survival of neural transplants to senescence in rats.

TitleLong-term survival of neural transplants to senescence in rats.
Publication TypeJournal Article
Year of Publication1990
JournalExperimental neurology
Volume108
Issue2
Pagination105-8
ISSN0014-4886
Abstract

A critical issue for clinical and research applications of transplant techniques is the long-term survival of transplanted tissue and its effect on the host brain. In this study, entorhinal cortices from donor embryos were transplanted into the lesioned angular bundle of juvenile male Sprague-Dawley rats. Animals were maintained for 2 years and then sacrificed for histological and histochemical examinations. The results indicate that entorhinal transplants survive to old age and that both the host and transplant tissues maintain morphological features consistent with those of short-term neural grafts. An unexpected finding of this experiment was the persistence in the transplanted tissue and adjacent host cortex of a pattern of AChE staining which is typical of early postnatal development.

URLhttps://linkinghub.elsevier.com/retrieve/pii/0014-4886(90)90015-K
Short TitleExp Neurol
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