Mifepristone pretreatment reduces ethanol withdrawal severity in vivo.

TitleMifepristone pretreatment reduces ethanol withdrawal severity in vivo.
Publication TypeJournal Article
Year of Publication2013
JournalAlcoholism, clinical and experimental research
Volume37
Issue8
Pagination1417-23
ISSN0145-6008
Abstract

Prolonged ethanol (EtOH) intake may perturb function of the hypothalamic-pituitary-adrenal axis in a manner that promotes dependence and influences EtOH withdrawal severity. Prior in vivo and in vitro studies suggest that corticosteroids, in particular, may be elevated during EtOH intoxication and withdrawal, suggesting that intracellular glucocorticoid receptors (GRs) may promote the development of EtOH dependence.

URLhttps://doi.org/10.1111/acer.12093
DOI10.1111/acer.12093
Short TitleAlcohol Clin Exp Res
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