A non-circadian role for clock-genes in sleep homeostasis: a strain comparison.

TitleA non-circadian role for clock-genes in sleep homeostasis: a strain comparison.
Publication TypeJournal Article
Year of Publication2007
JournalBMC neuroscience
Volume8
Pagination87
Date Published2007
Abstract

We have previously reported that the expression of circadian clock-genes increases in the cerebral cortex after sleep deprivation (SD) and that the sleep rebound following SD is attenuated in mice deficient for one or more clock-genes. We hypothesized that besides generating circadian rhythms, clock-genes also play a role in the homeostatic regulation of sleep. Here we follow the time course of the forebrain changes in the expression of the clock-genes period (per)-1, per2, and of the clock-controlled gene albumin D-binding protein (dbp) during a 6 h SD and subsequent recovery sleep in three inbred strains of mice for which the homeostatic sleep rebound following SD differs. We reasoned that if clock genes are functionally implicated in sleep homeostasis then the SD-induced changes in gene expression should vary according to the genotypic differences in the sleep rebound.

URLhttps://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-8-87
DOI10.1186/1471-2202-8-87
Short TitleBMC Neurosci
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