A novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms.

TitleA novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms.
Publication TypeJournal Article
Year of Publication2007
JournalSleep
Volume30
Issue10
Pagination1255-63
ISSN0161-8105
Abstract

The mammalian circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus conveys 24-h rhythmicity to sleep-wake cycles, locomotor activity, and other behavioral and physiological processes. The timing of rhythms relative to the light/dark (LD12:12) cycle is influenced in part by the endogenous circadian period and the time of day specific sensitivity of the clock to light. We now describe a novel circadian rhythm phenotype, and a locus influencing that phenotype, in a segregating population of mice.

Short TitleSleep
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