Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

TitlePentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
Publication TypeJournal Article
JournalPloS one
Volume9
Issue3
Paginatione89621
Date Published2014
Abstract

We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a role in heart failure development.

URLhttp://dx.plos.org/10.1371/journal.pone.0089621
DOI10.1371/journal.pone.0089621
Short TitlePLoS One
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