A position-effect assay for boundaries of higher order chromosomal domains.

TitleA position-effect assay for boundaries of higher order chromosomal domains.
Publication TypeJournal Article
Year of Publication1991
JournalCell
Volume64
Issue5
Pagination941-50
Date Published1991
ISSN0092-8674
Abstract

Eukaryotic chromosomes are thought to be organized into a series of discrete higher order chromatin domains. This organization is believed to be important not only in the compaction of the chromatin fiber, but also in the utilization of genetic information. Each domain would define an independent unit of gene activity, insulated from the regulatory influences of adjacent domains. Critical to this model of chromosome organization and function are the domain boundaries: the special nucleoprotein structures that delimit each higher order domain and segregate the chromosome into units of independent gene activity. In the work reported here we have tested whether two putative domain boundaries, scs and scs', from the Drosophila 87A7 heat shock locus can establish a domain of independent gene activity in vivo and insulate against chromosomal position effects.

URLhttp://linkinghub.elsevier.com/retrieve/pii/0092-8674(91)90318-S
Short TitleCell
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