Role of melanopsin in circadian responses to light.

TitleRole of melanopsin in circadian responses to light.
Publication TypeJournal Article
Year of Publication2002
JournalScience (New York, N.Y.)
Volume298
Issue5601
Pagination2211-3
Date Published2002
ISSN0036-8075
Abstract

Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=12481140
DOI10.1126/science.1076701
Short TitleScience
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