Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal.

TitleSex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal.
Publication TypeJournal Article
Year of Publication1969
JournalAlcohol and alcoholism (Oxford, Oxfordshire)
Volume44
Issue6
Pagination567-74
Date Published1969
ISSN0735-0414
Abstract

Caffeine is a central nervous system stimulant that produces its primary effects via antagonism of the A(1) and A(2A) adenosine receptor subtypes. Previous work demonstrated a sex difference in neurotoxicity produced by specific adenosine A(1) receptor antagonism during ethanol withdrawal (EWD) in vitro that was attributable to effects downstream of A(1) receptors at NMDA receptors. The current studies were designed to examine the effect of non-specific adenosine receptor antagonism with caffeine during ethanol withdrawal on hippocampal toxicity in cultures derived from male and female rats.

URLhttps://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agp050
DOI10.1093/alcalc/agp050
Short TitleAlcohol Alcohol
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