Stability of the glutamate content of synaptosomes during their preparation.

TitleStability of the glutamate content of synaptosomes during their preparation.
Publication TypeJournal Article
Year of Publication1980
JournalNeurochemical research
Volume5
Issue10
Pagination1107-16
ISSN0364-3190
Abstract

The glutamate content of synaptosomal-enriched fractions is stable during the preparation and isolation of the organelles provided that the temperature of the preparation is maintained at 0--2 degrees C and that inorganic ions are not added to the homogenizing and centrifugation media. Consequently, drug-induced in vivo changes in the glutamate content of nerve endings should be reflected by the corresponding changes in glutamate levels of synaptosomes prepared from the brain tissue.

Short TitleNeurochem Res
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