Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.

TitleSyndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.
Publication TypeJournal Article
JournalPloS one
Volume10
Issue1
Paginatione0117404
Date Published2015
Abstract

Tissue factor (TF) pathway inhibitor (TFPI) exists in two isoforms; TFPIα and TFPIβ. Both isoforms are cell surface attached mainly through glycosylphosphatidylinositol (GPI) anchors. TFPIα has also been proposed to bind other surface molecules, like glycosaminoglycans (GAGs). Cell surface TFPIβ has been shown to exert higher anticoagulant activity than TFPIα, suggesting alternative functions for TFPIα. Further characterization and search for novel TFPI binding partners is crucial to completely understand the biological functions of cell associated TFPI.

URLhttp://dx.plos.org/10.1371/journal.pone.0117404
DOI10.1371/journal.pone.0117404
Short TitlePLoS One
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