Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

TitleTerfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.
Publication TypeJournal Article
Year of Publication2015
JournalOrganic letters
Volume17
Issue11
Pagination2796-9
Date Published2015
ISSN1523-7060
Abstract

Terfestatins B (1) and C (2), new p-terphenyls bearing a novel unsaturated hexuronic acid (4-deoxy-α-L-threo-hex-4-enopyranuronate), a unique β-D-glycosyl ester of 5-isoprenylindole-3-carboxylate (3) and the same rare sugar, and two new hygromycin precursors, were characterized as metabolites of the coal mine fire isolate Streptomyces sp. RM-5-8. EtOH damage neuroprotection assays using rat hippocampal-derived primary cell cultures with 1, 2, 3 and echoside B (a terfestatin C-3'-β-D-glucuronide from Streptomyces sp. RM-5-8) revealed 1 as potently neuroprotective, highlighting a new potential application of the terfestatin scaffold.

URLhttps://dx.doi.org/10.1021/acs.orglett.5b01203
DOI10.1021/acs.orglett.5b01203
Short TitleOrg Lett
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading