Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus.

TitleUrethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus.
Publication TypeJournal Article
Year of Publication2008
JournalMutation research
Volume657
Issue2
Pagination160-3
Date Published2008
ISSN0027-5107
Abstract

Urethane and N-nitrosodiethylamine are soluble environmental carcinogens that initiate tumors transplacentally, but have a mixed history of effectiveness in mutagenesis assays in vitro or in vivo with adult rodents. To test for their transplacental mutagenicity, Syrian hamster fetuses at 12 days in gestation were exposed transplacentally to urethane or N-nitrosodiethylamine at 0.5 or 1.0 mM/kg. The fetal cells were isolated on day 13 of gestation and tested for diphtheria toxin resistance as a mutation marker. Both compounds were significantly mutagenic, at both doses, causing 6- to 20-fold increases in mutations compared with controls. Compared with N-nitrosodiethylamine, urethane was somewhat more effective as a mutagen with a more marked dose-response. These results are consistent with mutagenesis as part of the mechanism of transplacental carcinogenicity of urethane and N-nitrosodiethylamine.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1383-5718(08)00226-X
DOI10.1016/j.mrgentox.2008.07.011
Short TitleMutat Res
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