James W Geddes
PubMed Publications*:
- "S-acylation regulates the membrane association and activity of Calpain-5."Biochimica et biophysica acta. Molecular cell research1869.9(2022):119298.Details. Full text
- "Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology."Cells10.2(2021):Details. Full text
- "The C2 domain of calpain 5 contributes to enzyme activation and membrane localization."Biochimica et biophysica acta. Molecular cell research1868.7(2021):119019.Details. Full text
- "Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury."International journal of molecular sciences23.1(2021):Details. Full text
- "Calpastatin Overexpression Protects against Excitotoxic Hippocampal Injury and Traumatic Spinal Cord Injury."Journal of neurotrauma37.21(2020):2268-2276.Details. Full text
- "Repositioning Flubendazole for Spinal Cord Injury."Journal of neurotrauma36.18(2019):2618-2630.Details. Full text
- "Current status of fluid biomarkers in mild traumatic brain injury."Experimental neurology275 Pt 3.(2016):334-352.Details. Full text
- "Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses."Investigative ophthalmology & visual science57.6(2016):2509-21.Details. Full text
- "Phage display for identification of serum biomarkers of traumatic brain injury."Journal of neuroscience methods272.(2016):33-37.Details. Full text
- "Ketone bodies mediate antiseizure effects through mitochondrial permeability transition."Annals of neurology78.1(2015):77-87.Details. Full text
- "Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies."The Journal of biological chemistry289.28(2014):19383-94.Details. Full text
- "Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model."Molecular neurobiology49.3(2014):1282-92.Details. Full text
- "Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury."Neuroscience256.(2014):163-9.Details. Full text
- "Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model."Journal of neurochemistry125.1(2013):125-32.Details. Full text
- "Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats."Journal of neurotrauma30.6(2013):427-33.Details. Full text
- "WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering."Current biology : CB22.7(2012):596-600.Details. Full text
- "Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease."Journal of chemical neuroanatomy42.2(2011):118-26.Details. Full text
- "A multi-mode shock tube for investigation of blast-induced traumatic brain injury."Journal of neurotrauma28.1(2011):95-104.Details. Full text
- "Color changing photonic crystals detect blast exposure."NeuroImage54 Suppl 1.(2011):S37-44.Details. Full text
- "Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release."Neuromolecular medicine13.1(2011):31-6.Details. Full text
- "Targeting individual calpain isoforms for neuroprotection."Experimental neurology226.1(2010):6-7.Details. Full text
- "Involvement of ERK2 in traumatic spinal cord injury."Journal of neurochemistry113.1(2010):131-42.Details. Full text
- "Calpain 1 and Calpastatin expression is developmentally regulated in rat brain."Experimental neurology220.2(2009):316-9.Details. Full text
- "Special Issue: Mitochondria and neurodegeneration."Experimental neurology218.2(2009):169-70.Details. Full text
- "Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor."Experimental neurology218.2(2009):221-7.Details. Full text
- "N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity."Neurochemical research34.3(2009):490-8.Details. Full text
- "Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury."Journal of neurotrauma25.7(2008):833-40.Details. Full text
- "N terminus of calpain 1 is a mitochondrial targeting sequence."The Journal of biological chemistry283.6(2008):3409-3417.Details. Full text
- "High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition."The Journal of neuroscience : the official journal of the Society for Neuroscience27.28(2007):7469-75.Details. Full text
- "Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury."Neurochemical research32.12(2007):2046-53.Details. Full text
- "Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde."Journal of neuroscience methods163.1(2007):38-43.Details. Full text
- "Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria."The Journal of biological chemistry281.17(2006):11658-68.Details. Full text
- "Mitochondrial localization of mu-calpain."Biochemical and biophysical research communications338.2(2005):1241-7.Details. Full text
- "alpha-Synuclein: a potent inducer of tau pathology."Experimental neurology192.2(2005):244-50.Details. Full text
- "Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons."Journal of Alzheimer's disease : JAD7.1(2005):15-24.Details. Full text
- "X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord."Histology and histopathology20.2(2005):519-30.Details. Full text
- "Nicotine attenuates morphological deficits in a contusion model of spinal cord injury."Journal of neurotrauma22.2(2005):240-51.Details. Full text
- "Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium."Journal of bioenergetics and biomembranes36.4(2004):401-6.Details.
- "Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria."Journal of neuroscience methods137.2(2004):299-303.Details. Full text
- "Tat-calpastatin fusion proteins transduce primary rat cortical neurons but do not inhibit cellular calpain activity."Experimental neurology188.1(2004):161-70.Details. Full text
- "Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma."Brain research. Molecular brain research124.2(2004):188-98.Details. Full text
- "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses."Proceedings of the National Academy of Sciences of the United States of America101.7(2004):2173-8.Details. Full text
- "Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology."Journal of neuropathology and experimental neurology62.6(2003):633-43.Details. Full text
- "Glutamate regulates caveolin expression in rat hippocampal neurons."Journal of neuroscience research72.2(2003):185-90.Details. Full text
- "Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid."Neurochemistry international43.2(2003):89-99.Details. Full text
- "Evaluation of conditions for calpain inhibition in the rat spinal cord: effective postinjury inhibition with intraspinal MDL28170 microinjection."Journal of neurotrauma20.1(2003):59-67.Details. Full text
- "3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease."Neurochemical research27.6(2002):507-11.Details.
- "Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury."Journal of neurotrauma19.4(2002):491-502.Details. Full text
- "Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease."Journal of neurochemistry75.4(2000):1709-15.Details. Full text
- "Cytoskeletal disruption following contusion injury to the rat spinal cord."Journal of neuropathology and experimental neurology59.4(2000):287-96.Details. Full text
- "3-nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease."Brain research858.2(2000):356-62.Details. Full text
- "Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42."Journal of neurochemistry73.4(1999):1584-9.Details. Full text
- "Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues."Brain research831.1-2(1999):104-12.Details. Full text
- "Neuroprotective effects of gelsolin during murine stroke."The Journal of clinical investigation103.3(1999):347-54.Details. Full text
- "6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions."Experimental neurology154.2(1998):637-44.Details. Full text
- "Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia."Brain research810.1-2(1998):181-99.Details. Full text
- "Regional levels of phospholipase Cgamma after fluid percussion brain injury in the rat."Brain research808.1(1998):116-9.Details. Full text
- "Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain."Journal of neuropathology and experimental neurology57.10(1998):972-8.Details. Full text
- "Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease."Nature medicine4.8(1998):957-62.Details. Full text
- "N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits."Journal of neuropathology and experimental neurology57.1(1998):76-94.Details. Full text
- "Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment."Journal of neurochemistry69.4(1997):1592-600.Details. Full text
- "Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal."Journal of neurochemistry69.1(1997):273-84.Details. Full text
- "Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis."The Journal of neuroscience : the official journal of the Society for Neuroscience17.9(1997):3064-73.Details. Full text
- "Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation."The Journal of neuroscience : the official journal of the Society for Neuroscience17.3(1997):1046-54.Details. Full text
- "Microtubular proteolysis in focal cerebral ischemia."Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism16.6(1996):1189-202.Details. Full text
- "Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain."Neuroscience letters210.3(1996):205-8.Details. Full text
- "Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801."Journal of neurochemistry66.2(1996):474-84.Details. Full text
- "Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response."Journal of neuroscience research42.3(1995):357-70.Details. Full text
- "Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia."Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism14.4(1994):554-64.Details. Full text
- "Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus."Hippocampus4.2(1994):210-25.Details. Full text
- "Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2."Brain research633.1-2(1994):1-8.Details. Full text
- "Familial influence on plaque formation in the beagle brain."Neuroreport3.12(1992):1093-6.Details.
- "Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors."Neuroscience50.1(1992):23-34.Details. Full text
- "N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease."Neuroscience49.1(1992):45-61.Details. Full text
- "Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease."Neuroscience48.4(1992):763-77.Details. Full text
- "Alterations in 3H kainate and N-methyl-D-aspartate-sensitive L- 3H -glutamate binding in the rat hippocampal formation following fimbria-fornix lesions."Experimental neurology115.2(1992):271-81.Details. Full text
- "Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in Alzheimer's disease."Journal of neuroscience research30.1(1991):183-91.Details. Full text
- "Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation."Experimental neurology112.1(1991):72-8.Details.
- "Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy."Experimental neurology108.3(1990):214-20.Details.
- "Long-term survival of neural transplants to senescence in rats."Experimental neurology108.2(1990):105-8.Details. Full text
- "Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease."Neuroscience letters109.1-2(1990):54-61.Details. Full text
- "Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease."Proceedings of the National Academy of Sciences of the United States of America86.21(1989):8284-8.Details. Full text
- "Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor."Nature341.6242(1989):546-9.Details. Full text
- " 3H TCP binding sites in Alzheimer's disease."Neuroscience letters73.2(1987):197-200.Details. Full text
- "Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease."Brain research399.1(1986):156-61.Details. Full text
- "Senile plaques as aberrant sprout-stimulating structures."Experimental neurology94.3(1986):767-76.Details.
- "Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease."Neuroscience research3.6(1986):672-8.Details. Full text
- "Plasticity of hippocampal circuitry in Alzheimer's disease."Science (New York, N.Y.)230.4730(1985):1179-81.Details. Full text
- "Methionine-induced changes in glutamate, aspartate, glutamine, and gamma-aminobutyrate levels in brain tissue."Journal of neurochemistry45.3(1985):777-83.Details. Full text
- "Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid."Journal of neurochemistry42.1(1984):16-24.Details. Full text
- "Combined effects of a metabolic inhibitor (gabaculine) and an uptake inhibitor (ketamine) on the gamma-aminobutyrate system in mouse brain."Journal of neurochemistry39.6(1982):1710-5.Details. Full text
- "Stability of the glutamate content of synaptosomes during their preparation."Neurochemical research5.10(1980):1107-16.Details.
- "N-terminus truncated beta-amyloid peptides and C-terminus truncated secreted forms of amyloid precursor protein: distinct roles in the pathogenesis of Alzheimer's disease."Neurobiology of aging20.1(1969):75-9; discussion 87.Details. Full text
- "Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease."Neurobiology of aging18.4 Suppl(1969):S99-105.Details. Full text
- "Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions."Neurobiology of aging18.3(1969):305-8.Details. Full text
- "Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease."Molecular and chemical neuropathology28.1-3(1969):65-74.Details.
- "Age-specific onset of beta-amyloid in beagle brains."Neurobiology of aging17.2(1969):269-73.Details. Full text
- "Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains."Neurobiology of aging17.2(1969):249-57.Details. Full text
- "Perikaryal accumulation and proteolysis of neurofilament proteins in the post-mortem rat brain."Neurobiology of aging16.4(1969):651-60.Details. Full text
- "Plasticity in Alzheimer's disease: too much or not enough?"Neurobiology of aging12.4(1969):330-3; discussion 352-5.Details. Full text
- "Protein L-isoaspartyl methyltransferase in postmortem brains of aged humans."Neurobiology of aging12.1(1969):19-24.Details. Full text
- "Plasticity, pathology, and Alzheimer's disease."Neurobiology of aging10.5(1969):571-3; discussion 588-90.Details. Full text
- "N-methyl-D-aspartate receptors and Alzheimer's disease."Neurobiology of aging10.5(1969):603-5; discussion 618-20.Details. Full text
- "Protein oxidation in the brain in Alzheimer's disease."Neuroscience103.2(0):373-83.Details. Full text
- "Does dopamine contribute to striatal damage caused by impaired mitochondrial function?"Annals of the New York Academy of Sciences893.(0):345-9.Details. Full text
- "Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?"Progress in brain research83.(0):427-34.Details. Full text
- "Increased expression of the major embryonic alpha-tubulin mRNA, T alpha 1, during neuronal regeneration, sprouting, and in Alzheimer's disease."Progress in brain research86.(0):321-30.Details. Full text
- "Molecular markers of reactive plasticity."Advances in experimental medicine and biology268.(0):425-32.Details.
- "Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease."Progress in brain research86.(0):55-61.Details. Full text
- "Excitotoxic amino acid receptors in human complex partial epilepsy."Stereotactic and functional neurosurgery54-55.(0):21-4.Details. Full text
- "Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker."Neuroscience38.2(0):515-25.Details. Full text
- "N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio)."Neuroscience32.1(0):39-47.Details. Full text
- "Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury."PloS one11.1(0):e0147716.Details. Full text
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