Sheldon Steiner
Education
Ph.D. University of Kentucky, 1967
Research
Neuron Astrocyte Signal Transduction
The long term goal of studies in my laboratory is to understand the role of lipid biomediators, in neuronal degeneration. Lipid biomediators include a wide range of compounds such as prostaglandins, leukotrienes, platelet activating factor lysophosphatidic acid (LPA), tumor necrosis factor and various cytokines. Currently, we are examining the role of LPA in signaling pathways associated with neuronal degeneration (apoptosis) as a model for Alzheimers disease and head trauma. We utilize primary neurons primary astrocytes, primary microglial cells and immortalized neuronally derived cultures cells (for gene transfer studies) as our model systems. These studies suggest that lipid biomediators, in particular LPA likely play a role in neuronal degeneration.
BIO 308
GENERAL MICROBIOLOGY Fall-2012 Syllabus.docx(19.67 KB)
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There will be a review in room BS 107 on Tuesday Oct 9 at 5pm
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BIO 308
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BIO 308-2013
PubMed Publications*:
- "Assessment of Online Patient Education Material About Dysphagia."Dysphagia(2022):Details. Full text
- "Multiple astrocyte responses to lysophosphatidic acids."Biochimica et biophysica acta1582.1-3(2002):154-60.Details. Full text
- "Lysophosphatidic acid induction of neuronal apoptosis and necrosis."Annals of the New York Academy of Sciences905.(2000):132-41.Details. Full text
- "Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations."Journal of neuroscience research56.5(1999):457-70.Details. Full text
- "Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD."Journal of neuroimmunology93.1-2(1999):53-71.Details. Full text
- "Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells."Journal of neuroscience research53.6(1998):685-96.Details. Full text
- "Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons."Journal of neurochemistry70.1(1998):66-76.Details. Full text
- "Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction."The Journal of neuroscience : the official journal of the Society for Neuroscience18.2(1998):687-97.Details. Full text
- "Lysophosphatidic acid-induced proliferation-related signals in astrocytes."Journal of neurochemistry69.3(1997):1073-84.Details. Full text
- "Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium."Journal of neurochemistry69.1(1997):68-75.Details. Full text
- "Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes."Journal of neurochemistry67.6(1996):2300-5.Details. Full text
- "Regulation of prostaglandin H synthase 1 and 2 in MyoD transfected cells."Experimental cell research218.1(1995):389-93.Details. Full text
- "Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation."Brain research654.1(1994):171-6.Details. Full text
- "MyoD and regulation of prostaglandin H synthase."Experimental cell research207.2(1993):439-41.Details. Full text
- "Growth factor responsiveness: role of MyoD and myogenin."Experimental cell research202.1(1992):105-12.Details. Full text
- "Prostaglandin endoperoxide synthase (cyclooxygenase) mRNA and protein production in mouse myoblasts and a differentiation-defective variant."Experimental cell research192.2(1991):643-6.Details.
- "Possible role of prostaglandins in the regulation of mouse myoblasts."Journal of cellular physiology141.1(1989):142-7.Details. Full text
- "Extracellular and cellular proteins of rat cells with O-glycosidically linked fucose."The Biochemical journal225.1(1985):59-65.Details. Full text
- "Metabolism of a transformation-sensitive amino acid fucoside in normal and simian virus 40-transformed human embryonic lung cells."Cancer research44.10(1984):4476-9.Details.
- "Characterization of an amino acid fucoside of normal and SV40-transformed human embryonic lung cells."Cancer research42.8(1982):3022-7.Details.
- "Characterization of novel amino acid fucosides."The Journal of biological chemistry256.15(1981):7932-5.Details. Full text
- "Assessment of attachment of Neisseria gonorrhoeae to HeLa cells by double radiolabeling."Infection and immunity25.3(1979):1043-50.Details. Full text
- "Metabolism of galactose in herpes simplex virus-infected cells."Virology69.1(1976):216-28.Details. Full text
- "Fucosylglycolipids in cells transformed by a temperature-sensitive mutant of murine sarcoma virus."Nature248.5450(1974):682-4.Details. Full text
- "Effects of 2-deoxy-D-glucose on herpes simplex virus replication."Virology52.2(1973):447-55.Details.
- "Possible role of prostaglandins in the regulation of mouse myoblasts."Progress in clinical and biological research343.(0):29-40.Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
