Di Domenico, F. ., Tramutola, A. ., Barone, E. ., Lanzillotta, C. ., Defever, O. ., Arena, A. ., … Perluigi, M. . (2019). Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome. Redox Biology, 23, 101162. https://doi.org/10.1016/j.redox.2019.101162

Sharma, N. ., Tramutola, A. ., Lanzillotta, C. ., Arena, A. ., Blarzino, C. ., Cassano, T. ., … Barone, E. . (2019). Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer’s disease. Neurobiology of Disease, 125, 176-189. https://doi.org/10.1016/j.nbd.2019.02.003

Tramutola, A. ., Lanzillotta, C. ., Barone, E. ., Arena, A. ., Zuliani, I. ., Mosca, L. ., … Di Domenico, F. . Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome. Translational Neurodegeneration, 7, 28. https://doi.org/10.1186/s40035-018-0133-9 (Original work published 2018)

Di Domenico, F. ., Pupo, G. ., Mancuso, C. ., Barone, E. ., Paolini, F. ., Arena, A. ., … Perluigi, M. . Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer’s disease. Journal of Alzheimer’s Disease : JAD, 44(4), 1107-20. https://doi.org/10.3233/JAD-141254 (Original work published 2015)

Barone, E. ., Arena, A. ., Head, E. ., Butterfield, D. ., & Perluigi, M. . (2018). Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism. Free Radical Biology & Medicine, 114, 84-93. https://doi.org/10.1016/j.freeradbiomed.2017.07.009

Tramutola, A. ., Pupo, G. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Lanzillotta, C. ., … Perluigi, M. . Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer’s Disease : JAD, 52(1), 359-371. https://doi.org/10.3233/JAD-151105 (Original work published 2016)

Barone, E. ., Di Domenico, F. ., Cassano, T. ., Arena, A. ., Tramutola, A. ., Lavecchia, M. ., … Perluigi, M. . (2016). Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radical Biology & Medicine, 91, 127-42. https://doi.org/10.1016/j.freeradbiomed.2015.12.012

Tramutola, A. ., Arena, A. ., Cini, C. ., Butterfield, D. ., & Barone, E. . (2017). Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology. Expert Review of Neurotherapeutics, 17(1), 59-75. https://doi.org/10.1080/14737175.2017.1246183

Tramutola, A. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Giorgi, A. ., di Francesco, L. ., … Perluigi, M. . (2017). Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxidants & Redox Signaling, 26(7), 280-298. https://doi.org/10.1089/ars.2016.6686 (Original work published 2017)