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The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer.

Author
Abstract
:

Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention. Hu antigen R (HuR), which is highly upregulated in CRC, functions as a pivotal oncogene to promote CRC progression. However, the underlying cause of its dysregulation is poorly understood.

Year of Publication
:
2018
Journal
:
Molecular cancer
Volume
:
17
Issue
:
1
Number of Pages
:
11
Date Published
:
2018
URL
:
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0751-3
DOI
:
10.1186/s12943-017-0751-3
Short Title
:
Mol Cancer
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