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<sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N resonance assignment of human YAP 50-171 fragment.

Author
Abstract
:

Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy. The TEAD binding domain of YAP was mapped to protein residues 50-171. To obtain further structural insights into this 12 kDa segment of YAP, we report a backbone and a partial sidechain assignment of recombinant YAP 50-171.

Year of Publication
:
2018
Journal
:
Biomolecular NMR assignments
Date Published
:
2018
ISSN Number
:
1874-2718
DOI
:
10.1007/s12104-018-9805-8
Short Title
:
Biomol NMR Assign
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