Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats.
Author | |
Abstract |
:
Proinflammatory eicosanoids (cyclooxgenase and lipoxygenase metabolites of arachidonic acid) released by alveolar macrophages play an important role in endotoxin-induced acute lung injury. We investigated the effect of prefeeding rats for 21 days with enteral diets that provided the anti-inflammatory fatty acids, eicosapentaenoic acid and gamma-linolenic acid (derived from fish oil and borage oil, respectively), as compared with an n-6 fatty acid-enriched diet (corn oil) on the following: a) lung microvascular protein permeability, arterial blood pressure, and platelet and white blood cells in a model of endotoxin-induced acute lung injury; b) alveolar macrophage prostaglandin and leukotriene synthesis; and c) liver and alveolar macrophage phospholipid fatty acid composition. |
Year of Publication |
:
1997
|
Journal |
:
Critical care medicine
|
Volume |
:
25
|
Issue |
:
3
|
Number of Pages |
:
523-32
|
ISSN Number |
:
0090-3493
|
URL |
:
https://dx.doi.org/10.1097/00003246-199703000-00024
|
DOI |
:
10.1097/00003246-199703000-00024
|
Short Title |
:
Crit Care Med
|
Download citation |