Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.
| Author | |
| Abstract |
:
A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain. |
| Year of Publication |
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2017
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| Journal |
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The Journal of nutritional biochemistry
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| Volume |
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39
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| Number of Pages |
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169-179
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| ISSN Number |
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0955-2863
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| URL |
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https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(16)30192-9
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| DOI |
:
10.1016/j.jnutbio.2016.10.006
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| Short Title |
:
J Nutr Biochem
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| Download citation |
