Unhealthy weight control behaviors (UWCBs) can lead to numerous health problems. Adolescents who engage in UWCB are more likely to abuse substances than other adolescents. However, few studies have examined the relationship between UWCB and substance use, despite the fact that their co-occurrence can result in greater morbidity and mortality. The aim of this study was to examine the association between UWCB and substance use patterns among Korean adolescents using nationally representative data.