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Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.

Author
Abstract
:

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

Year of Publication
:
2020
Journal
:
Dalton transactions (Cambridge, England : 2003)
Volume
:
49
Issue
:
35
Number of Pages
:
12161-12167
Date Published
:
2020
ISSN Number
:
1477-9226
URL
:
https://doi.org/10.1039/d0dt02016h
DOI
:
10.1039/d0dt02016h
Short Title
:
Dalton Trans
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