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The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.

Author
Abstract
:

Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shors, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if so, when. The authors found that excitotoxic lesions to the BNST prevented the enhanced conditioning after stressor exposure. In addition, temporary inactivation of the BNST during the stressor did not alter enhanced responding, whereas inactivation during training prevented the enhancement. These data indicate that stressful experience induces persistent changes in the BNST that are necessary for enhancing learning well after the stressful event has ceased.

Year of Publication
:
2005
Journal
:
Behavioral neuroscience
Volume
:
119
Issue
:
6
Number of Pages
:
1459-66
ISSN Number
:
0735-7044
URL
:
http://content.apa.org/journals/bne/119/6/1459
DOI
:
10.1037/0735-7044.119.6.1459
Short Title
:
Behav Neurosci
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