BACKGROUND The contemporary risk classification criteria of gastrointestinal stromal tumors (GISTs) may still have room to improve. The aim of our research was to analyze the impact factors for GIST patients' relapse-free survival (RFS). Furthermore, we explore whether gastrointestinal (1) bleeding will be a valuable indicator to predict GIST patients' prognosis. MATERIAL AND METHODS R0 resection GISTs patients were retrospectively enrolled during an 8-year period at West China Hospital of Sichuan University, and all patients' data were from the WCHSU-GIST database. Of a total of 333 GIST patients, 164 patients had GI bleeding. Univariate analysis and Cox regression analysis were used to calculate the survival and recurrence rates. RESULTS Compared with non-GI-bleeding patients, GI-bleeding patients had a shorter relapse-free survival (RFS, P=0.003), but among the different risk groups, GI bleeding only affected the RFS rate of the high-risk group. A Cox regression analysis illustrated that tumor site (P<0.001), tumor size (P=0.009), mitotic index (P<0.001), tumor rupture (P<0.001), and GI-bleeding (P=0.01) were independent indicators for GIST patients' RFS. CONCLUSIONS Our study demonstrates that the RFS of GIST patients with GI bleeding was significantly shorter than that of non-GI-bleeding patients, and GI bleeding was an independent negative factor predicting RFS, while GI bleeding had more influence among high-risk patients.